Drug interactions
Fosamprenavir + Sertraline
Severity: Moderate
Fosamprenavir and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (converted to amprenavir, often boosted with ritonavir) inhibits CYP3A4 and may raise sertraline concentrations. This could increase serotonergic and other dose-related adverse effects.
What this interaction means in plain words
Fosamprenavir and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated sertraline metabolism by amprenavir, with possible variable effects from ritonavir.
What to do
Start sertraline at a low dose and titrate to clinical response. Monitor for nausea, tremor, agitation and other signs of excess serotonergic effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Fosamprenavir with Sertraline?
MediHelp rates the interaction as moderate. Fosamprenavir and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir (converted to amprenavir, often boosted with ritonavir) inhibits CYP3A4 and may raise sertraline concentrations. This could increase serotonergic and other dose-related adverse effects.
How serious is the interaction between Fosamprenavir and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start sertraline at a low dose and titrate to clinical response. Monitor for nausea, tremor, agitation and other signs of excess serotonergic effect.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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