Drug interactions
Fosamprenavir + Sitagliptin
Severity: Minor
Fosamprenavir and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors can induce insulin resistance and hyperglycemia, which may reduce the effectiveness of sitagliptin. The effect varies between patients and agents.
What this interaction means in plain words
Fosamprenavir and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic opposition through protease-inhibitor-associated insulin resistance.
What to do
Monitor blood glucose and HbA1c after starting or stopping fosamprenavir. Adjust antidiabetic treatment as required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Fosamprenavir with Sitagliptin?
MediHelp rates the interaction as minor. Fosamprenavir and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Protease inhibitors can induce insulin resistance and hyperglycemia, which may reduce the effectiveness of sitagliptin. The effect varies between patients and agents.
How serious is the interaction between Fosamprenavir and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping fosamprenavir. Adjust antidiabetic treatment as required.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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