Drug interactions
Fosamprenavir + Ticagrelor
Severity: Major
Fosamprenavir and Ticagrelor: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, via amprenavir, inhibits CYP3A4, and when boosted with ritonavir the inhibition is strong. This may raise ticagrelor levels, increasing bleeding risk and dyspnea.
What this interaction means in plain words
Fosamprenavir and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4-mediated ticagrelor metabolism by amprenavir.
What to do
Avoid with boosted regimens in line with labeling for strong CYP3A inhibitors. If unavoidable, monitor closely for bleeding or choose another antiplatelet.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Fosamprenavir with Ticagrelor?
MediHelp rates the interaction as major. Fosamprenavir and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosamprenavir, via amprenavir, inhibits CYP3A4, and when boosted with ritonavir the inhibition is strong. This may raise ticagrelor levels, increasing bleeding risk and dyspnea.
How serious is the interaction between Fosamprenavir and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with boosted regimens in line with labeling for strong CYP3A inhibitors. If unavoidable, monitor closely for bleeding or choose another antiplatelet.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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