Drug interactions
Fosamprenavir + Tinidazole
Severity: Minor
Fosamprenavir and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (as amprenavir) inhibits CYP3A4 and may raise tinidazole levels. The clinical effect is probably small given tinidazole's wide safety margin.
What this interaction means in plain words
Fosamprenavir and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 reduces tinidazole clearance.
What to do
No routine adjustment; monitor for tinidazole adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Fosamprenavir with Tinidazole?
MediHelp rates the interaction as minor. Fosamprenavir and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosamprenavir (as amprenavir) inhibits CYP3A4 and may raise tinidazole levels. The clinical effect is probably small given tinidazole's wide safety margin.
How serious is the interaction between Fosamprenavir and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for tinidazole adverse effects.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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