Drug interactions
Fosamprenavir + Tolazamide
Severity: Moderate
Fosamprenavir and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors such as amprenavir (the active form of fosamprenavir) can cause insulin resistance and hyperglycemia, reducing the control achieved with tolazamide. Effects on tolazamide exposure are unpredictable.
What this interaction means in plain words
Fosamprenavir and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitor-induced insulin resistance and impaired glucose metabolism, with possible minor CYP-mediated changes in sulfonylurea levels.
What to do
Monitor blood glucose and HbA1c when fosamprenavir is started or stopped. Adjust tolazamide or add other antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Fosamprenavir with Tolazamide?
MediHelp rates the interaction as moderate. Fosamprenavir and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors such as amprenavir (the active form of fosamprenavir) can cause insulin resistance and hyperglycemia, reducing the control achieved with tolazamide. Effects on tolazamide exposure are unpredictable.
How serious is the interaction between Fosamprenavir and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when fosamprenavir is started or stopped. Adjust tolazamide or add other antidiabetic therapy as needed.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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