Drug interactions
Fosamprenavir + Ziprasidone
Severity: Moderate
Fosamprenavir and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amprenavir, the active metabolite of fosamprenavir, inhibits CYP3A4 and may increase ziprasidone levels, especially when boosted with ritonavir. Higher exposure could add to QT prolongation.
What this interaction means in plain words
Fosamprenavir and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by amprenavir, with or without ritonavir, reducing ziprasidone clearance.
What to do
Obtain an ECG and check electrolytes at the start of therapy. Use the lowest effective ziprasidone dose and monitor for sedation and QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Fosamprenavir with Ziprasidone?
MediHelp rates the interaction as moderate. Fosamprenavir and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amprenavir, the active metabolite of fosamprenavir, inhibits CYP3A4 and may increase ziprasidone levels, especially when boosted with ritonavir. Higher exposure could add to QT prolongation.
How serious is the interaction between Fosamprenavir and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check electrolytes at the start of therapy. Use the lowest effective ziprasidone dose and monitor for sedation and QT prolongation.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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