Drug interactions
Foscarnet + Ivosidenib
Severity: Major
Foscarnet and Ivosidenib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib is associated with dose-related QT prolongation, and foscarnet can also prolong the QT interval. Together they may increase the risk of torsade de pointes, particularly if foscarnet causes electrolyte depletion.
What this interaction means in plain words
Foscarnet and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Foscarnet belongs to Anti Virals; Ivosidenib belongs to Oncology.
Why it happens
Additive QT prolongation, with foscarnet-related electrolyte disturbances adding risk.
What to do
Avoid the combination where possible. If it cannot be avoided, monitor ECG and electrolytes more often and reduce or interrupt ivosidenib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Foscarnet with Ivosidenib?
MediHelp rates the interaction as major. Foscarnet and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib is associated with dose-related QT prolongation, and foscarnet can also prolong the QT interval. Together they may increase the risk of torsade de pointes, particularly if foscarnet causes electrolyte depletion.
How serious is the interaction between Foscarnet and Ivosidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it cannot be avoided, monitor ECG and electrolytes more often and reduce or interrupt ivosidenib if QTc becomes markedly prolonged.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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