Drug interactions
Foscarnet + Pamidronate
Severity: Moderate
Foscarnet and Pamidronate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower serum calcium: pamidronate by inhibiting bone resorption and foscarnet by chelating ionized calcium. Together they may cause symptomatic hypocalcemia with tetany, paresthesias or seizures.
What this interaction means in plain words
Foscarnet and Pamidronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Foscarnet belongs to Anti Virals; Pamidronate belongs to Musculoskeletal.
Why it happens
Additive lowering of serum calcium through bone resorption inhibition and chelation of ionized calcium.
What to do
Check calcium, magnesium and ionized calcium before and during therapy, and correct deficits promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pamidronate
- Aluminum hydroxide + Pamidronate Moderate
- Dichlorphenamide + Pamidronate Moderate
- Pamidronate + Tenofovir df Moderate
- Pamidronate + Tenofovir disoproxil Moderate
- Calcium carbonate + Pamidronate Minor
- Calcium + Pamidronate Minor
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Pamidronate?
MediHelp rates the interaction as moderate. Foscarnet and Pamidronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower serum calcium: pamidronate by inhibiting bone resorption and foscarnet by chelating ionized calcium. Together they may cause symptomatic hypocalcemia with tetany, paresthesias or seizures.
How serious is the interaction between Foscarnet and Pamidronate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check calcium, magnesium and ionized calcium before and during therapy, and correct deficits promptly.
What other medicines interact with Pamidronate?
MediHelp also lists interactions of Pamidronate with, for example, Aluminum hydroxide, Dichlorphenamide, Tenofovir df. The full list is on the Pamidronate page.
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