Drug interactions
Foscarnet + Paroxetine
Severity: Moderate
Foscarnet and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine has a small QT effect, and foscarnet can prolong QT and deplete electrolytes. The overall added risk is modest but relevant in patients with other risk factors.
What this interaction means in plain words
Foscarnet and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Foscarnet belongs to Anti Virals; Paroxetine belongs to Central Nervous System.
Why it happens
Additive QT prolongation with electrolyte disturbance.
What to do
Monitor electrolytes during foscarnet therapy and obtain an ECG in patients with cardiac disease or other QT-prolonging drugs. Correct hypokalemia, hypomagnesemia and hypocalcemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Foscarnet with Paroxetine?
MediHelp rates the interaction as moderate. Foscarnet and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine has a small QT effect, and foscarnet can prolong QT and deplete electrolytes. The overall added risk is modest but relevant in patients with other risk factors.
How serious is the interaction between Foscarnet and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes during foscarnet therapy and obtain an ECG in patients with cardiac disease or other QT-prolonging drugs. Correct hypokalemia, hypomagnesemia and hypocalcemia.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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