Drug interactions
Foscarnet + Pazopanib
Severity: Major
Foscarnet and Pazopanib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are associated with QT prolongation, and foscarnet commonly disturbs calcium, magnesium and potassium levels. The combination may increase the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Foscarnet and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Foscarnet belongs to Anti Virals; Pazopanib belongs to Oncology.
Why it happens
Additive QT prolongation, aggravated by foscarnet-induced electrolyte abnormalities.
What to do
Obtain a baseline ECG and correct electrolytes before starting, then monitor the QTc and electrolytes periodically. Consider an alternative if the QTc becomes significantly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Foscarnet with Pazopanib?
MediHelp rates the interaction as major. Foscarnet and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are associated with QT prolongation, and foscarnet commonly disturbs calcium, magnesium and potassium levels. The combination may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Foscarnet and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes before starting, then monitor the QTc and electrolytes periodically. Consider an alternative if the QTc becomes significantly prolonged.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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