Drug interactions
Foscarnet + Risedronate
Severity: Moderate
Foscarnet and Risedronate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Foscarnet chelates divalent cations and can cause symptomatic hypocalcemia, and bisphosphonates also lower serum calcium. Together the effect may be additive, with risk of tetany, seizures or arrhythmia.
What this interaction means in plain words
Foscarnet and Risedronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Foscarnet belongs to Anti Virals; Risedronate belongs to Musculoskeletal.
Why it happens
Additive lowering of serum ionized calcium via foscarnet chelation and bisphosphonate inhibition of bone resorption.
What to do
Correct hypocalcemia and vitamin D deficiency beforehand and monitor serum calcium, magnesium and potassium during foscarnet therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risedronate
- Aluminum hydroxide + Risedronate Moderate
- Calcium acetate + Risedronate Moderate
- Calcium carbonate + Risedronate Moderate
- Calcium chloride + Risedronate Moderate
- Calcium citrate + Risedronate Moderate
- Calcium gluconate + Risedronate Moderate
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Risedronate?
MediHelp rates the interaction as moderate. Foscarnet and Risedronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Foscarnet chelates divalent cations and can cause symptomatic hypocalcemia, and bisphosphonates also lower serum calcium. Together the effect may be additive, with risk of tetany, seizures or arrhythmia.
How serious is the interaction between Foscarnet and Risedronate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct hypocalcemia and vitamin D deficiency beforehand and monitor serum calcium, magnesium and potassium during foscarnet therapy.
What other medicines interact with Risedronate?
MediHelp also lists interactions of Risedronate with, for example, Aluminum hydroxide, Calcium acetate, Calcium carbonate. The full list is on the Risedronate page.
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