Drug interactions
Foscarnet + Streptomycin
Severity: Major
Foscarnet and Streptomycin: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Foscarnet commonly causes nephrotoxicity and electrolyte disturbances, and streptomycin is nephrotoxic and ototoxic. Together they raise the risk of renal injury and aminoglycoside accumulation. Electrolyte abnormalities may add to neuromuscular and cardiac risk.
What this interaction means in plain words
Foscarnet and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Foscarnet belongs to Anti Virals; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity, with reduced renal function increasing aminoglycoside exposure.
What to do
Avoid concurrent use if alternatives exist. Otherwise hydrate, monitor serum creatinine, calcium, magnesium, potassium and phosphate, and check streptomycin levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Streptomycin
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Streptomycin?
MediHelp rates the interaction as major. Foscarnet and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Foscarnet commonly causes nephrotoxicity and electrolyte disturbances, and streptomycin is nephrotoxic and ototoxic. Together they raise the risk of renal injury and aminoglycoside accumulation. Electrolyte abnormalities may add to neuromuscular and cardiac risk.
How serious is the interaction between Foscarnet and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if alternatives exist. Otherwise hydrate, monitor serum creatinine, calcium, magnesium, potassium and phosphate, and check streptomycin levels.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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