Drug interactions
Fosinopril + Gliclazide
Severity: Moderate
Fosinopril and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can increase insulin sensitivity and may enhance the glucose-lowering effect of sulfonylureas. Hypoglycemia has been reported, mainly after starting the ACE inhibitor.
What this interaction means in plain words
Fosinopril and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril belongs to Cardiovascular; Gliclazide belongs to Endocrine.
Why it happens
ACE inhibitors improve insulin sensitivity and glucose uptake, adding to sulfonylurea-induced insulin secretion.
What to do
Monitor blood glucose when fosinopril is initiated or the dose changed. Reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Fosinopril with Gliclazide?
MediHelp rates the interaction as moderate. Fosinopril and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can increase insulin sensitivity and may enhance the glucose-lowering effect of sulfonylureas. Hypoglycemia has been reported, mainly after starting the ACE inhibitor.
How serious is the interaction between Fosinopril and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fosinopril is initiated or the dose changed. Reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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