Drug interactions
Fosinopril + Glipizide-metformin
Severity: Moderate
Fosinopril and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors like fosinopril can improve insulin sensitivity and increase the hypoglycemic effect of sulfonylureas and metformin. Hypoglycemia is most likely in the first weeks of therapy. Renal function changes with ACE inhibitors can also affect metformin safety.
What this interaction means in plain words
Fosinopril and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril belongs to Cardiovascular; Glipizide-metformin belongs to Endocrine.
Why it happens
ACE inhibition enhances insulin sensitivity and may reduce renal function, which can increase metformin exposure.
What to do
Monitor blood glucose after starting the ACE inhibitor and check renal function periodically. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Fosinopril with Glipizide-metformin?
MediHelp rates the interaction as moderate. Fosinopril and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors like fosinopril can improve insulin sensitivity and increase the hypoglycemic effect of sulfonylureas and metformin. Hypoglycemia is most likely in the first weeks of therapy. Renal function changes with ACE inhibitors can also affect metformin safety.
How serious is the interaction between Fosinopril and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting the ACE inhibitor and check renal function periodically. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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