Drug interactions
Fosinopril + Glyburide-metformin
Severity: Moderate
Fosinopril and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and increase the risk of hypoglycemia in patients taking sulfonylureas or insulin. Renal impairment from ACE inhibition may also increase metformin accumulation and lactic acidosis risk.
What this interaction means in plain words
Fosinopril and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Enhanced insulin sensitivity through ACE inhibition and possible renal effects reducing metformin clearance.
What to do
Monitor blood glucose, especially after initiation or dose increases of fosinopril. Check renal function periodically and reduce antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Fosinopril with Glyburide-metformin?
MediHelp rates the interaction as moderate. Fosinopril and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and increase the risk of hypoglycemia in patients taking sulfonylureas or insulin. Renal impairment from ACE inhibition may also increase metformin accumulation and lactic acidosis risk.
How serious is the interaction between Fosinopril and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, especially after initiation or dose increases of fosinopril. Check renal function periodically and reduce antidiabetic doses as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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