Drug interactions
Fosinopril-hydrochlorothiazide + Ganciclovir
Severity: Minor
Fosinopril-hydrochlorothiazide and Ganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides may reduce the renal tubular secretion of ganciclovir, and ganciclovir is cleared mainly by the kidney. In addition, volume depletion from the diuretic can lower renal function and further raise ganciclovir exposure, increasing the risk of myelosuppression.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Ganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Ganciclovir belongs to Anti Virals.
Why it happens
Possible competition for renal tubular secretion plus diuretic-related reduction in renal function.
What to do
Monitor renal function and blood counts during ganciclovir therapy, and adjust the ganciclovir dose to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Ganciclovir
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Ganciclovir?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Ganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides may reduce the renal tubular secretion of ganciclovir, and ganciclovir is cleared mainly by the kidney. In addition, volume depletion from the diuretic can lower renal function and further raise ganciclovir exposure, increasing the risk of myelosuppression.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Ganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts during ganciclovir therapy, and adjust the ganciclovir dose to creatinine clearance.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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