Drug interactions
Fosinopril-hydrochlorothiazide + Gold sodium thiomalate
Severity: Moderate
Fosinopril-hydrochlorothiazide and Gold sodium thiomalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Injectable gold given with ACE inhibitors has been associated with nitritoid reactions, including flushing, nausea, vomiting and hypotension. Reactions are uncommon but can be distressing.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Gold sodium thiomalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Not well established; possibly related to bradykinin-mediated vasodilation with ACE inhibition.
What to do
Monitor for flushing and hypotension after gold injections; consider an alternative antihypertensive if reactions recur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fosinopril-hydrochlorothiazide and Gold sodium thiomalate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Gold sodium thiomalate?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Gold sodium thiomalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Injectable gold given with ACE inhibitors has been associated with nitritoid reactions, including flushing, nausea, vomiting and hypotension. Reactions are uncommon but can be distressing.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Gold sodium thiomalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for flushing and hypotension after gold injections; consider an alternative antihypertensive if reactions recur.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
