Drug interactions
Fosinopril-hydrochlorothiazide + Heparin
Severity: Moderate
Fosinopril-hydrochlorothiazide and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin suppresses aldosterone secretion and, with an ACE inhibitor, can lead to hyperkalemia, particularly in patients with renal impairment or diabetes or with prolonged therapy. The thiazide partly offsets this.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Heparin belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of aldosterone synthesis adds to ACE inhibitor-mediated potassium retention.
What to do
Monitor serum potassium when heparin is continued for more than a few days or in high-risk patients. Treat hyperkalemia and reassess therapy if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Heparin?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin suppresses aldosterone secretion and, with an ACE inhibitor, can lead to hyperkalemia, particularly in patients with renal impairment or diabetes or with prolonged therapy. The thiazide partly offsets this.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when heparin is continued for more than a few days or in high-risk patients. Treat hyperkalemia and reassess therapy if it occurs.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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