Drug interactions
Fosinopril-hydrochlorothiazide + Indapamide
Severity: Moderate
Fosinopril-hydrochlorothiazide and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two thiazide-type diuretics provides little added benefit and increases the risk of hypokalemia, hyponatremia, hypomagnesemia and volume depletion. Hydrochlorothiazide is already part of the fixed combination.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Duplicate thiazide-type inhibition of the distal tubule sodium-chloride cotransporter with additive electrolyte loss.
What to do
Avoid therapeutic duplication unless specifically intended for resistant edema; if used, monitor sodium, potassium and renal function closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Indapamide
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Indapamide?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two thiazide-type diuretics provides little added benefit and increases the risk of hypokalemia, hyponatremia, hypomagnesemia and volume depletion. Hydrochlorothiazide is already part of the fixed combination.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid therapeutic duplication unless specifically intended for resistant edema; if used, monitor sodium, potassium and renal function closely.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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