Drug interactions
Fosinopril-hydrochlorothiazide + Insulin inhaled
Severity: Moderate
Fosinopril-hydrochlorothiazide and Insulin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can cause hyperglycemia and reduce insulin response, while ACE inhibitors may increase insulin sensitivity and hypoglycemia risk. Glycemic control may shift when either drug is changed.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced impaired glucose tolerance, partly via hypokalemia, versus ACE inhibitor enhancement of insulin sensitivity.
What to do
Monitor blood glucose when starting, stopping or adjusting the combination and titrate insulin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Insulin inhaled?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides can cause hyperglycemia and reduce insulin response, while ACE inhibitors may increase insulin sensitivity and hypoglycemia risk. Glycemic control may shift when either drug is changed.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Insulin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, stopping or adjusting the combination and titrate insulin dose accordingly.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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