Drug interactions
Fosinopril-hydrochlorothiazide + Insulin regular human
Severity: Moderate
Fosinopril-hydrochlorothiazide and Insulin regular human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may increase the glucose-lowering effect of insulin, raising the risk of hypoglycemia. Thiazides such as hydrochlorothiazide tend to raise blood glucose, so the net effect on glycemic control can vary.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition enhances insulin sensitivity (pharmacodynamic synergism), while thiazide-induced hyperglycemia may oppose insulin effects.
What to do
Monitor blood glucose more frequently when starting or changing the combination, especially in the first weeks. Adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Insulin regular human?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and may increase the glucose-lowering effect of insulin, raising the risk of hypoglycemia. Thiazides such as hydrochlorothiazide tend to raise blood glucose, so the net effect on glycemic control can vary.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Insulin regular human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or changing the combination, especially in the first weeks. Adjust the insulin dose as needed.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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