Drug interactions
Fosinopril-hydrochlorothiazide + Levalbuterol
Severity: Moderate
Fosinopril-hydrochlorothiazide and Levalbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both levalbuterol and hydrochlorothiazide can lower serum potassium, and their combined effect may cause clinically significant hypokalemia. This may predispose to arrhythmias, especially at high beta-agonist doses.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonists shift potassium into cells while thiazides cause renal potassium loss, producing additive hypokalemia.
What to do
Monitor serum potassium, particularly with frequent or high-dose levalbuterol. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Levalbuterol?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both levalbuterol and hydrochlorothiazide can lower serum potassium, and their combined effect may cause clinically significant hypokalemia. This may predispose to arrhythmias, especially at high beta-agonist doses.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Levalbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly with frequent or high-dose levalbuterol. Replace potassium as needed.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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