Drug interactions
Fosinopril-hydrochlorothiazide + Magnesium sulfate
Severity: Minor
Fosinopril-hydrochlorothiazide and Magnesium sulfate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide increases urinary magnesium loss and can lead to hypomagnesemia during long-term use. Magnesium sulfate given to correct deficiency may be needed in larger or repeated amounts while the thiazide continues.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide diuretics increase renal magnesium excretion.
What to do
Monitor serum magnesium and potassium during long-term thiazide therapy and adjust the magnesium dose to the measured level.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Magnesium sulfate?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide increases urinary magnesium loss and can lead to hypomagnesemia during long-term use. Magnesium sulfate given to correct deficiency may be needed in larger or repeated amounts while the thiazide continues.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Magnesium sulfate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and potassium during long-term thiazide therapy and adjust the magnesium dose to the measured level.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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