Drug interactions
Fosinopril-hydrochlorothiazide + Meclofenamate
Severity: Moderate
Fosinopril-hydrochlorothiazide and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate can diminish the blood pressure effect of fosinopril and hydrochlorothiazide. The triple effect on renal hemodynamics can precipitate acute kidney injury, especially in older or volume-depleted patients.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, opposing ACE inhibitor and diuretic action.
What to do
Monitor blood pressure, creatinine and potassium, ensure hydration, and use the lowest NSAID dose for the shortest time or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Meclofenamate?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate can diminish the blood pressure effect of fosinopril and hydrochlorothiazide. The triple effect on renal hemodynamics can precipitate acute kidney injury, especially in older or volume-depleted patients.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium, ensure hydration, and use the lowest NSAID dose for the shortest time or choose an alternative analgesic.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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