Drug interactions
Fosinopril-hydrochlorothiazide + Metaproterenol
Severity: Moderate
Fosinopril-hydrochlorothiazide and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol and hydrochlorothiazide can each lower serum potassium, and together may cause significant hypokalemia with a risk of arrhythmia.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonist-driven cellular potassium uptake combined with thiazide renal potassium loss.
What to do
Monitor serum potassium and correct deficits. Use the lowest effective beta-agonist dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Metaproterenol?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaproterenol and hydrochlorothiazide can each lower serum potassium, and together may cause significant hypokalemia with a risk of arrhythmia.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and correct deficits. Use the lowest effective beta-agonist dose.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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