Drug interactions
Fosinopril-hydrochlorothiazide + Metformin
Severity: Moderate
Fosinopril-hydrochlorothiazide and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may slightly improve glycemic control, which can occasionally lead to lower glucose in patients treated with metformin. Thiazides can raise glucose and, with ACE inhibitors, may reduce renal function, which would increase metformin accumulation and the risk of lactic acidosis.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Altered insulin sensitivity from ACE inhibition, plus potential reduction in renal function that decreases metformin clearance.
What to do
Monitor glucose and renal function regularly, and reassess metformin dosing if eGFR declines. Hold metformin during acute illness with dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Metformin
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Metformin?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may slightly improve glycemic control, which can occasionally lead to lower glucose in patients treated with metformin. Thiazides can raise glucose and, with ACE inhibitors, may reduce renal function, which would increase metformin accumulation and the risk of lactic acidosis.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function regularly, and reassess metformin dosing if eGFR declines. Hold metformin during acute illness with dehydration.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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