Drug interactions
Fosinopril-hydrochlorothiazide + Mycophenolate
Severity: Minor
Fosinopril-hydrochlorothiazide and Mycophenolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may compete with mycophenolic acid glucuronide for renal tubular secretion, potentially raising levels of the metabolite. The clinical significance is uncertain.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular secretion of acidic (anionic) compounds.
What to do
No routine adjustment; monitor for mycophenolate adverse effects such as cytopenias.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Mycophenolate?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may compete with mycophenolic acid glucuronide for renal tubular secretion, potentially raising levels of the metabolite. The clinical significance is uncertain.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Mycophenolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for mycophenolate adverse effects such as cytopenias.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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