Drug interactions
Fosinopril-hydrochlorothiazide + Nesiritide
Severity: Moderate
Fosinopril-hydrochlorothiazide and Nesiritide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nesiritide is a vasodilator, and combining it with ACE inhibitors and diuretics can lead to additive hypotension. Symptomatic hypotension is the main concern.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Nesiritide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilatory and hypotensive effects.
What to do
Monitor blood pressure closely during nesiritide infusion. Reduce the infusion rate or hold other antihypertensives if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Nesiritide?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Nesiritide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nesiritide is a vasodilator, and combining it with ACE inhibitors and diuretics can lead to additive hypotension. Symptomatic hypotension is the main concern.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Nesiritide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during nesiritide infusion. Reduce the infusion rate or hold other antihypertensives if hypotension occurs.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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