Drug interactions
Fosinopril-hydrochlorothiazide + Noni juice
Severity: Moderate
Fosinopril-hydrochlorothiazide and Noni juice: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Noni juice has a high potassium content and may raise serum potassium, which is relevant with an ACE inhibitor that reduces potassium excretion. The thiazide component lowers potassium, so the net effect is unpredictable, and hyperkalemia has been reported with noni juice in patients with renal impairment.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Noni juice can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Dietary potassium load combined with ACE inhibitor reduction of aldosterone-mediated potassium excretion, partly offset by thiazide potassium wasting.
What to do
Avoid regular noni juice intake in patients with renal impairment, and check serum potassium if the juice is consumed regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Noni juice?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Noni juice can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Noni juice has a high potassium content and may raise serum potassium, which is relevant with an ACE inhibitor that reduces potassium excretion. The thiazide component lowers potassium, so the net effect is unpredictable, and hyperkalemia has been reported with noni juice in patients with renal impairment.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Noni juice?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular noni juice intake in patients with renal impairment, and check serum potassium if the juice is consumed regularly.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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