Drug interactions
Fosinopril-hydrochlorothiazide + Norepinephrine
Severity: Moderate
Fosinopril-hydrochlorothiazide and Norepinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Catecholamines can lower serum potassium, and with hydrochlorothiazide this may worsen hypokalemia. Thiazides may also reduce the pressor response to norepinephrine.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Adrenergic cellular potassium uptake plus thiazide kaliuresis; thiazides may reduce vascular responsiveness to pressors.
What to do
Monitor serum potassium and blood pressure during norepinephrine infusion. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Norepinephrine?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Catecholamines can lower serum potassium, and with hydrochlorothiazide this may worsen hypokalemia. Thiazides may also reduce the pressor response to norepinephrine.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Norepinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during norepinephrine infusion. Replace potassium as needed.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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