Drug interactions
Fosinopril-hydrochlorothiazide + Olanzapine / samidorphan
Severity: Minor
Fosinopril-hydrochlorothiazide and Olanzapine / samidorphan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension and may add to the blood pressure lowering of ACE inhibitors and thiazides. This can lead to dizziness, syncope or falls, especially in older patients or at the start of treatment.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Olanzapine / samidorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic hypotension from olanzapine alpha-adrenergic blockade combined with antihypertensive effects.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating olanzapine. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Olanzapine / samidorphan?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Olanzapine / samidorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Olanzapine can cause orthostatic hypotension and may add to the blood pressure lowering of ACE inhibitors and thiazides. This can lead to dizziness, syncope or falls, especially in older patients or at the start of treatment.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Olanzapine / samidorphan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating olanzapine. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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