Drug interactions
Fosinopril-hydrochlorothiazide + Parecoxib
Severity: Moderate
Fosinopril-hydrochlorothiazide and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib can blunt the antihypertensive effect of ACE inhibitors and thiazides. The combination also raises the risk of acute kidney injury, especially with volume depletion.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandins causes sodium retention and reduced renal perfusion, opposing ACE inhibitor and diuretic effects.
What to do
Monitor blood pressure, renal function and potassium, and ensure adequate hydration. Use the shortest course of parecoxib possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Parecoxib?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib can blunt the antihypertensive effect of ACE inhibitors and thiazides. The combination also raises the risk of acute kidney injury, especially with volume depletion.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium, and ensure adequate hydration. Use the shortest course of parecoxib possible.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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