Drug interactions
Fosinopril-hydrochlorothiazide + Salicylates
Severity: Moderate
Fosinopril-hydrochlorothiazide and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates can reduce prostaglandin-dependent renal blood flow, which may blunt the antihypertensive effect of ACE inhibitors and diuretics and worsen renal function in volume-depleted or elderly patients. The effect is generally smaller than with conventional NSAIDs.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal vasodilatory prostaglandins reduces antihypertensive efficacy and glomerular perfusion.
What to do
Monitor blood pressure, renal function and potassium, and ensure adequate hydration. Use the lowest effective salicylate dose or switch to paracetamol if analgesia alone is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Salicylates?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates can reduce prostaglandin-dependent renal blood flow, which may blunt the antihypertensive effect of ACE inhibitors and diuretics and worsen renal function in volume-depleted or elderly patients. The effect is generally smaller than with conventional NSAIDs.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium, and ensure adequate hydration. Use the lowest effective salicylate dose or switch to paracetamol if analgesia alone is needed.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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