Drug interactions
Fosinopril-hydrochlorothiazide + Salsalate
Severity: Moderate
Fosinopril-hydrochlorothiazide and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate can attenuate the antihypertensive effect of fosinopril and hydrochlorothiazide and may impair renal function, especially in dehydrated or elderly patients or those with kidney disease.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced synthesis of vasodilatory renal prostaglandins lowers renal perfusion and sodium excretion.
What to do
Monitor blood pressure, creatinine and potassium when salsalate is started or changed, and maintain hydration; consider paracetamol as alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Salsalate?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate can attenuate the antihypertensive effect of fosinopril and hydrochlorothiazide and may impair renal function, especially in dehydrated or elderly patients or those with kidney disease.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium when salsalate is started or changed, and maintain hydration; consider paracetamol as alternative.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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