Drug interactions
Fosinopril-hydrochlorothiazide + Sodium citrate / citric acid
Severity: Minor
Fosinopril-hydrochlorothiazide and Sodium citrate / citric acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium citrate is an alkalinizing sodium salt and a source of sodium that may counteract blood pressure control. Combined with a thiazide, alkalinization may also aggravate metabolic alkalosis and potassium loss. Clinically significant effects are uncommon with occasional use.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Sodium load and systemic alkalinization may oppose antihypertensive effects and add to thiazide-induced hypokalemia.
What to do
Monitor blood pressure and serum potassium and bicarbonate if used regularly or in patients with heart failure or renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Sodium citrate / citric acid?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium citrate is an alkalinizing sodium salt and a source of sodium that may counteract blood pressure control. Combined with a thiazide, alkalinization may also aggravate metabolic alkalosis and potassium loss. Clinically significant effects are uncommon with occasional use.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Sodium citrate / citric acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium and bicarbonate if used regularly or in patients with heart failure or renal impairment.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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