Drug interactions
Fosinopril-hydrochlorothiazide + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Major
Fosinopril-hydrochlorothiazide and Sodium sulfate / ?magnesium sulfate / potassium chloride: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osmotic bowel preparations cause fluid loss and electrolyte shifts, and taking them with an ACE inhibitor and a diuretic increases the risk of volume depletion, acute kidney injury and electrolyte abnormalities. Severe disturbances can lead to arrhythmias or seizures.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Sodium sulfate / ?magnesium sulfate / potassium chloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive volume depletion and electrolyte disturbance from the bowel preparation and the diuretic, with ACE inhibitor-related impairment of renal autoregulation.
What to do
Hold the diuretic-containing combination on the day of bowel preparation per product guidance and ensure adequate oral fluids. Check electrolytes and renal function in high-risk patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as major. Fosinopril-hydrochlorothiazide and Sodium sulfate / ?magnesium sulfate / potassium chloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Osmotic bowel preparations cause fluid loss and electrolyte shifts, and taking them with an ACE inhibitor and a diuretic increases the risk of volume depletion, acute kidney injury and electrolyte abnormalities. Severe disturbances can lead to arrhythmias or seizures.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold the diuretic-containing combination on the day of bowel preparation per product guidance and ensure adequate oral fluids. Check electrolytes and renal function in high-risk patients.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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