Drug interactions
Fosinopril-hydrochlorothiazide + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Moderate
Fosinopril-hydrochlorothiazide and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid and electrolyte shifts and diarrhea, and thiazide diuretics add to volume and electrolyte depletion. The ACE inhibitor raises the risk of acute kidney injury when volume depleted. This combination can cause dehydration, electrolyte disturbances and kidney injury.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive fluid and electrolyte losses with thiazide diuresis, and impaired renal autoregulation from ACE inhibition during volume depletion.
What to do
Consider withholding the diuretic and ACE inhibitor on the day of bowel preparation, and ensure adequate hydration. Check electrolytes and renal function in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fosinopril-hydrochlorothiazide and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid and electrolyte shifts and diarrhea, and thiazide diuretics add to volume and electrolyte depletion. The ACE inhibitor raises the risk of acute kidney injury when volume depleted. This combination can cause dehydration, electrolyte disturbances and kidney injury.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding the diuretic and ACE inhibitor on the day of bowel preparation, and ensure adequate hydration. Check electrolytes and renal function in high-risk patients.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
