Drug interactions
Fosinopril-hydrochlorothiazide + Sulfasalazine
Severity: Minor
Fosinopril-hydrochlorothiazide and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is not a typical NSAID and has little prostaglandin inhibition, so the blood pressure antagonism described for NSAIDs is not well established. Rare renal toxicity with sulfasalazine could add to renal risk with an ACE inhibitor and diuretic, but a consistent interaction is not documented.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; possible additive renal effects.
What to do
No routine change needed; monitor renal function periodically, especially in elderly or volume-depleted patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Sulfasalazine?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is not a typical NSAID and has little prostaglandin inhibition, so the blood pressure antagonism described for NSAIDs is not well established. Rare renal toxicity with sulfasalazine could add to renal risk with an ACE inhibitor and diuretic, but a consistent interaction is not documented.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed; monitor renal function periodically, especially in elderly or volume-depleted patients.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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