Drug interactions
Fosinopril-hydrochlorothiazide + Synthetic human angiotensin ii
Severity: Moderate
Fosinopril-hydrochlorothiazide and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors reduce endogenous angiotensin II formation, which may increase the pressor response to infused angiotensin II, and the labeling for angiotensin II notes that patients on ACE inhibitors may have an increased response. Diuretic-induced volume depletion alters responsiveness as well.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic: ACE inhibition leads to upregulated receptor sensitivity so exogenous angiotensin II produces a greater pressor effect.
What to do
Start angiotensin II at the lowest dose and titrate to blood pressure with continuous hemodynamic monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fosinopril-hydrochlorothiazide and Synthetic human angiotensin ii, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors reduce endogenous angiotensin II formation, which may increase the pressor response to infused angiotensin II, and the labeling for angiotensin II notes that patients on ACE inhibitors may have an increased response. Diuretic-induced volume depletion alters responsiveness as well.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start angiotensin II at the lowest dose and titrate to blood pressure with continuous hemodynamic monitoring.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
