Drug interactions
Fosinopril-hydrochlorothiazide + Terbutaline
Severity: Moderate
Fosinopril-hydrochlorothiazide and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbutaline and hydrochlorothiazide both lower serum potassium, so combined use can cause clinically relevant hypokalemia. This may provoke arrhythmias, particularly with high-dose or nebulized terbutaline. The fosinopril component partly offsets potassium loss.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Beta-2 agonism shifts potassium into cells while thiazides increase renal potassium loss, producing additive hypokalemia.
What to do
Monitor serum potassium, especially with high or frequent terbutaline dosing, and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Terbutaline
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Terbutaline?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbutaline and hydrochlorothiazide both lower serum potassium, so combined use can cause clinically relevant hypokalemia. This may provoke arrhythmias, particularly with high-dose or nebulized terbutaline. The fosinopril component partly offsets potassium loss.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially with high or frequent terbutaline dosing, and replace potassium as needed.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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