Drug interactions
Fosinopril-hydrochlorothiazide + Umeclidinium bromide / vilanterol inhaled
Severity: Minor
Fosinopril-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a beta-agonist, can lower serum potassium, and hydrochlorothiazide does the same. Combined hypokalemia may provoke ECG changes or arrhythmias, especially if the beta-agonist dose is exceeded.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypokalemia from beta-2 stimulated intracellular potassium shift and thiazide renal potassium loss.
What to do
Use the inhaler at the labeled dose and monitor serum potassium in patients with additional risk factors. Correct hypokalemia if present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vilanterol, a beta-agonist, can lower serum potassium, and hydrochlorothiazide does the same. Combined hypokalemia may provoke ECG changes or arrhythmias, especially if the beta-agonist dose is exceeded.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the inhaler at the labeled dose and monitor serum potassium in patients with additional risk factors. Correct hypokalemia if present.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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