Drug interactions
Fosinopril-hydrochlorothiazide + Zotepine
Severity: Moderate
Fosinopril-hydrochlorothiazide and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine has alpha-adrenergic blocking properties that cause orthostatic hypotension, and this adds to the blood pressure lowering of an ACE inhibitor and diuretic. The effect is most noticeable when starting or increasing zotepine.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from antipsychotic alpha-1 blockade and ACE inhibitor/diuretic effects.
What to do
Titrate zotepine slowly and monitor blood pressure and orthostatic symptoms, reducing the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Zotepine?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine has alpha-adrenergic blocking properties that cause orthostatic hypotension, and this adds to the blood pressure lowering of an ACE inhibitor and diuretic. The effect is most noticeable when starting or increasing zotepine.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate zotepine slowly and monitor blood pressure and orthostatic symptoms, reducing the antihypertensive dose if hypotension occurs.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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