Drug interactions
Fosphenytoin + Lesinurad
Severity: Minor
Fosphenytoin and Lesinurad: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosphenytoin, via phenytoin, induces CYP enzymes and may lower lesinurad levels. This may weaken its uric acid lowering effect.
What this interaction means in plain words
Fosphenytoin and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosphenytoin belongs to Central Nervous System; Lesinurad belongs to Genitourinary.
Why it happens
Phenytoin induces CYP2C9, accelerating lesinurad metabolism.
What to do
Monitor serum uric acid and gout flares when starting or stopping fosphenytoin. Consider alternative urate-lowering therapy if response is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Fosphenytoin with Lesinurad?
MediHelp rates the interaction as minor. Fosphenytoin and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosphenytoin, via phenytoin, induces CYP enzymes and may lower lesinurad levels. This may weaken its uric acid lowering effect.
How serious is the interaction between Fosphenytoin and Lesinurad?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout flares when starting or stopping fosphenytoin. Consider alternative urate-lowering therapy if response is lost.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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