Drug interactions
Fostemsavir + Glibenclamide
Severity: Minor
Fostemsavir and Glibenclamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's active metabolite temsavir inhibits the OATP1B1/3 and BCRP transporters, which take part in glyburide uptake and efflux. Exposure to glyburide may therefore rise, increasing the likelihood of hypoglycemia. The effect is probably modest in most patients.
What this interaction means in plain words
Fostemsavir and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostemsavir belongs to Anti Virals; Glibenclamide belongs to Endocrine.
Why it happens
Temsavir inhibits OATP1B1/3 and BCRP transporters, reducing hepatic uptake and efflux of glyburide.
What to do
Monitor blood glucose when fostemsavir is started or stopped in a patient taking glyburide. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Glibenclamide?
MediHelp rates the interaction as minor. Fostemsavir and Glibenclamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostemsavir's active metabolite temsavir inhibits the OATP1B1/3 and BCRP transporters, which take part in glyburide uptake and efflux. Exposure to glyburide may therefore rise, increasing the likelihood of hypoglycemia. The effect is probably modest in most patients.
How serious is the interaction between Fostemsavir and Glibenclamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fostemsavir is started or stopped in a patient taking glyburide. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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