Drug interactions
Fostemsavir + Hydrochlorothiazide-olmesartan
Severity: Minor
Fostemsavir and Hydrochlorothiazide-olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The fostemsavir metabolite temsavir inhibits OATP1B1/1B3, which transport olmesartan into the liver. Olmesartan levels may rise, increasing its blood pressure lowering and adverse effects. The effect is expected to be modest.
What this interaction means in plain words
Fostemsavir and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostemsavir belongs to Anti Virals; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1/1B3 hepatic uptake reduces olmesartan clearance.
What to do
Monitor blood pressure, renal function and potassium. Lower the olmesartan dose if hypotension or other adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as minor. Fostemsavir and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The fostemsavir metabolite temsavir inhibits OATP1B1/1B3, which transport olmesartan into the liver. Olmesartan levels may rise, increasing its blood pressure lowering and adverse effects. The effect is expected to be modest.
How serious is the interaction between Fostemsavir and Hydrochlorothiazide-olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium. Lower the olmesartan dose if hypotension or other adverse effects occur.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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