Drug interactions
Fostemsavir + Levosalbutamol
Severity: Moderate
Fostemsavir and Levosalbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir has been associated with QTc prolongation at supratherapeutic doses, and beta-agonists such as levosalbutamol can contribute to QT prolongation, particularly with hypokalemia. At usual doses the combined risk is small but may matter in patients with other QT risk factors.
What this interaction means in plain words
Fostemsavir and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Levosalbutamol belongs to Respiratory.
Why it happens
Additive QTc prolongation; beta-agonist induced hypokalemia may further raise arrhythmia risk.
What to do
Obtain an ECG and check potassium and magnesium in patients with additional QT risk factors or heart disease. Keep fostemsavir at the recommended dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Levosalbutamol?
MediHelp rates the interaction as moderate. Fostemsavir and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir has been associated with QTc prolongation at supratherapeutic doses, and beta-agonists such as levosalbutamol can contribute to QT prolongation, particularly with hypokalemia. At usual doses the combined risk is small but may matter in patients with other QT risk factors.
How serious is the interaction between Fostemsavir and Levosalbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check potassium and magnesium in patients with additional QT risk factors or heart disease. Keep fostemsavir at the recommended dose.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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