Drug interactions
Fostemsavir + Olmesartan
Severity: Minor
Fostemsavir and Olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's active metabolite temsavir inhibits OATP1B1/1B3, which are involved in olmesartan hepatic uptake. Olmesartan exposure may increase modestly, with limited expected clinical consequence.
What this interaction means in plain words
Fostemsavir and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostemsavir belongs to Anti Virals; Olmesartan belongs to Cardiovascular.
Why it happens
Temsavir inhibits OATP1B1/1B3 transporters, which may reduce hepatic uptake of olmesartan and raise plasma levels.
What to do
Monitor blood pressure and renal function and potassium when the combination is started. Reduce the olmesartan dose if hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Olmesartan?
MediHelp rates the interaction as minor. Fostemsavir and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostemsavir's active metabolite temsavir inhibits OATP1B1/1B3, which are involved in olmesartan hepatic uptake. Olmesartan exposure may increase modestly, with limited expected clinical consequence.
How serious is the interaction between Fostemsavir and Olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function and potassium when the combination is started. Reduce the olmesartan dose if hypotension develops.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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