Drug interactions
Fostemsavir + Pitavastatin
Severity: Moderate
Fostemsavir and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir may raise pitavastatin concentrations and increase the risk of myopathy. Exposure effects are expected from transporter inhibition.
What this interaction means in plain words
Fostemsavir and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Pitavastatin belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1/1B3 and BCRP by the active metabolite temsavir reduces pitavastatin clearance.
What to do
Use the lowest effective pitavastatin dose and monitor for muscle symptoms. Consider an alternative statin if problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Pitavastatin?
MediHelp rates the interaction as moderate. Fostemsavir and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir may raise pitavastatin concentrations and increase the risk of myopathy. Exposure effects are expected from transporter inhibition.
How serious is the interaction between Fostemsavir and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pitavastatin dose and monitor for muscle symptoms. Consider an alternative statin if problems arise.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporin, Erythromycin base, Erythromycin ethylsuccinate. The full list is on the Pitavastatin page.
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