Drug interactions
Fostemsavir + Terbutaline
Severity: Moderate
Fostemsavir and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir has caused QT prolongation at supratherapeutic doses, and terbutaline can cause tachycardia and hypokalemia that increase arrhythmia susceptibility. Combined use may modestly raise the risk of QT-related arrhythmia, mainly in patients with other risk factors.
What this interaction means in plain words
Fostemsavir and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Terbutaline belongs to Respiratory.
Why it happens
Additive QT-related effects: fostemsavir may delay repolarization and beta-2 agonist hypokalemia increases vulnerability.
What to do
Consider a baseline ECG and check potassium and magnesium in patients with cardiac risk factors. Avoid other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbutaline
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Terbutaline?
MediHelp rates the interaction as moderate. Fostemsavir and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir has caused QT prolongation at supratherapeutic doses, and terbutaline can cause tachycardia and hypokalemia that increase arrhythmia susceptibility. Combined use may modestly raise the risk of QT-related arrhythmia, mainly in patients with other risk factors.
How serious is the interaction between Fostemsavir and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a baseline ECG and check potassium and magnesium in patients with cardiac risk factors. Avoid other QT-prolonging drugs where possible.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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