Drug interactions
Frovatriptan + Imipramine
Severity: Moderate
Frovatriptan and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Use of a tricyclic antidepressant with frovatriptan carries a theoretical risk of serotonin syndrome. Cases are rare.
What this interaction means in plain words
Frovatriptan and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Frovatriptan belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects of imipramine reuptake inhibition and frovatriptan 5-HT1B/1D agonism.
What to do
Advise patients to report agitation, tremor, sweating or fever and stop the triptan if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Imipramine?
MediHelp rates the interaction as moderate. Frovatriptan and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Use of a tricyclic antidepressant with frovatriptan carries a theoretical risk of serotonin syndrome. Cases are rare.
How serious is the interaction between Frovatriptan and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report agitation, tremor, sweating or fever and stop the triptan if serotonin syndrome is suspected.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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